Abstract
Purpose: Osteoarthritis (OA) is a common bone and joint degenerative disease, typically characterized by progressive destruction of the extracellular matrix (ECM) of the cartilage. It is a complex condition owing to the limited repair potential of adult cartilage tissue. Tankyrase (encoded by TNKS/TNKS2) was recently identified as a potential new therapeutic target for OA. G007-LK highly selectively targets TNKS and TNKS2. However, tankyrase inhibition reportedly had negative systemic effects resulting in bone loss.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
