G Quadruplexes Stabilised by 8-Oxo-2′-deoxyguanosine

Abstract

G quadruplexes (GQPs) are four-stranded secondary structures formed of guanosine-rich nucleic acids. They consist of at least two G tetrads composed of four guanosine nucleotides. DNA GQPs have been shown to fold into a variety of different topologies that can be divided into antiparallel and parallel conformations (the latter is depicted in Figure 1 A).[!] The topology of DNA GQPs depends on the sequence and the loop length. For example, sequences with single nucleotide loops favour all-parallel strand orientationPJ Furthermore, the loop length also determines the stability of GQPs: the shorter the loop, the more stable is the