G proteins: introduction of its history, structure, function, and drug development

Abstract

G protein-coupled receptor can be written in GPCR, it has a big great family and this species include 800 human genes, it become the important part of human body. Although each species has their own unique skills, it can make different kind of medicine that can save humans life. And then there's the G-protein-coupled receptor mechanism. The GPCR desensitization regulator - arrestin was further analyzed, and researchers discovered that GPCRs could be activated not only through the G-protein-dependent pathway but also through the non-G-protein-dependent pathway, known as the -inhibitor pathway, to control the ingestion and desensitization throughout vivo and even start a new wave of signal transduction. The development of G-protein-coupled receptor drugs followed. GPCR is strongly associated to pathological conditions and has an essential function in cell signal transmission. More than 40% of the medicines on the market today target GPCR, which is the reached a high point family of pharmacological targets. The intracellular effector proteins (G proteins, etc.) that are activated by the GPCR play an important role in the regulation of its physiological function.