Abstract
Background: Susceptibility to sIBM is strongly associated with HLA-DRB1*03 and the 8.1 MHC ancestral haplotype but little is known about the effect of allelic interactions at the DRB1 locus or disease-modifying effects of HLA alleles. Objectives: To determine whether DRB1 allele interactions influence susceptibility to sIBM and disease phenotype. Patients & Methods: HLA-DRB1 genotyping was carried out in 80 biopsy-proven cases of sIBM using high-resolution DNA sequencing in 55 cases and serological typing in 25 cases.
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