Abstract
Human telomeres function as a protective structure capping the ends of chromosomes. They are shortened by repeated cell divisions and by oxidative DNA damage. When telomeres reach a critically low threshold, chromosomes become unstable and susceptible to rearrangements that can trigger cellular senescense or apoptosis. TRF1 and other telomere proteins regulate telomere stability and telomere length. Poly(ADP-ribose)polymerase 1 (PARP1) is well characterized for its role in base excision repair, where it is activated by and binds to DNA breaks and catalyzes the poly(ADP-ribosylation) of several substrates involved in DNA damage repair.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
