FZD2 Regulates Murine Hair Follicle Function and Maintenance

Abstract

Canonical Wnt signaling regulates hair follicle development and function in mice and humans (Andl et al., 2002; Choi et al., 2013; Heilmann et al., 2013; Lien et al., 2014; Millar, 2002; Xu et al., 2017). Secreted Wnt proteins bind to frizzled (FZD) family of G-protein coupled receptors, which in turn stabilizes and permits nuclear translocation of β-catenin with subsequent activation of target genes. Although several Wnt ligands critical to hair follicle function have been identified, the FZD receptors involved remain unknown (Heilmann et al., 2013; Kandyba and Kobielak, 2014; Reddy et al., 2001; Wu et al., 2019; Xu et al., 2017).