Future trends in antihypertensive therapy.

Abstract

SummaryAn attempt was made to replace the more conventional approach to antihypertensive therapy (cuff approach) by antihypertensive therapy based on physiopathological findings (physiopathological approach). The use of beta adrenergic blocking agents in hypertensive patients with high cardiac output and of peripheral vasodilating antihypertensive agents in patients with increased total peripheral resistance was discussed. Sodium depletion by diuretics and low sodium diet was advised in high plasma volume types of hypertension, but also in other hypertensive patients. The possibilities of a more specific antihypertensive therapy in patients with low and high plasma renin levels was assessed. The importance of a prognostic approach in the treatment of hypertensive patients was stressed.