Abstract
BackgroundWhether the delivery of a large-for-gestational-age (LGA) infant predicts future maternal metabolic syndrome (MetS) is not known. To this aim, we investigated the incidence of MetS and its components in women with or without a history of gestational diabetes mellitus (GDM) with a view to the birth weight of the offspring.MethodsEight hundred seventy six women treated for their pregnancies in Kuopio University Hospital in 1989–2009 underwent a follow-up study (mean follow-up time 7.3 (SD 5.1) years), of whom 489 women with GDM and 385 normoglycemic controls. The women were stratified into two groups according to the newborn’s birth weight: 10-90th percentile (appropriate-for-gestational-age; AGA) (n = 662) and > 90th percentile (LGA) (n = 116). MetS and its components were evaluated in the follow-up study according to the International Diabetes Federation criteria.ResultsLGA vs. AGA delivery was associated with a higher incidence of MetS at follow-up in women with a background of GDM (54.4% vs. 43.6%), but not in women without GDM.ConclusionAn LGA delivery in women with GDM is associated with a higher risk of future MetS and this group is optimal to study preventive measures for MetS. In contrast, an LGA delivery after a normoglycemic pregnancy was not associated with an increased future maternal MetS risk.
Highlights
Whether the delivery of a large-for-gestational-age (LGA) infant predicts future maternal metabolic syndrome (MetS) is not known
gestational diabetes mellitus (GDM) is associated with an increased risk of developing type 2 diabetes (T2DM) [1,2,3], metabolic syndrome (MetS) and cardiovascular diseases (CVD) [4,5,6,7,8] after the pregnancy
Women with GDM were older in both birth weight categories as compared to controls during the index pregnancy
Summary
Whether the delivery of a large-for-gestational-age (LGA) infant predicts future maternal metabolic syndrome (MetS) is not known. To this aim, we investigated the incidence of MetS and its components in women with or without a history of gestational diabetes mellitus (GDM) with a view to the birth weight of the offspring. We hypothesized that a previous LGA delivery would be associated with an increased risk of Hakkarainen et al BMC Pregnancy and Childbirth (2018) 18:326 incident MetS in the mother after the pregnancy To this aim, we investigated the incidence of MetS and its components in women with and without GDM by groups of different birth size
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