Future perspectives and trends in inflammation in cerebral ischemia-reperfusion injury: Based on bibliometric analysis

Abstract

BackgroundInflammation plays a crucial role in the initiation and progression of cerebral ischemia-reperfusion injury and has gained much scholarly interest. However, this research field has not yet been examined bibliometrically. We intended to utilize bibliometrics to highlight the research hotspots and developing trends of inflammation in cerebral ischemia-reperfusion injury and provide an objective foundation for basic and clinical research. MethodsThe Web of Science database was combed for articles relating to inflammation in cerebral ischemia-reperfusion injury from 2002 to 2022. CiteSpace and VOSviewer were used to visualize and analyze data pertaining to countries, institutions, journals, authors, references, and keywords. ResultsThere were a total of 1183 papers included in this analysis. Every year, the number of articles on inflammation research in cerebral ischemia-reperfusion injury increases. Brain Research and Stroke are, respectively, the most published and most cited academic journals in this discipline. We identified 646 scholars, with Zhao,jing producing the most publications and Longa EZ receiving the most citations. Inflammation, stroke, oxidative stress, and apoptosis were found to be the most frequently used terms after analysis. The main areas of current research on inflammation in cerebral ischemia-reperfusion injury involve non-coding rna, myeloperoxidase, Toll-like receptor-4, and neurotrophic factor. ConclusionThe importance of inflammation in cerebral ischemia-reperfusion injury diseases has been widely recognized. After decades of constant research, we are not yet sufficiently knowledgeable in this sector.Microglial activation, signaling pathway, protection and pathophysiology will be the new hot and new direction in this research field in the future.