Abstract
Historically and in general, pathologists have been on the perimeter of disease prognosis and therapy guidance. Their role has predominantly focused on analysing a specimen and interpreting a diagnostic result, including staging of malignancies. Decisions regarding the appropriate course of therapy typically have been outside the purview of pathology. However, during the past few years, as the first step toward personalised treatments, targeted therapies with companion molecular diagnostics have experienced a significant surge in development. These diagnostic developments span the course of a disease from pre-disposition, pre-dosage and post-dosage monitoring, and include understanding the genetic characteristics of the patient and the tumour that will directly influence therapy decisions. This presentation will explore the implications of this brave new world of personalised medicine for pathologists, with focus on treatment team interaction and quality standards expectations. Historically and in general, pathologists have been on the perimeter of disease prognosis and therapy guidance. Their role has predominantly focused on analysing a specimen and interpreting a diagnostic result, including staging of malignancies. Decisions regarding the appropriate course of therapy typically have been outside the purview of pathology. However, during the past few years, as the first step toward personalised treatments, targeted therapies with companion molecular diagnostics have experienced a significant surge in development. These diagnostic developments span the course of a disease from pre-disposition, pre-dosage and post-dosage monitoring, and include understanding the genetic characteristics of the patient and the tumour that will directly influence therapy decisions. This presentation will explore the implications of this brave new world of personalised medicine for pathologists, with focus on treatment team interaction and quality standards expectations.
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