Abstract
Expert Rev. Clin. Immunol. 4(6), 647–648 (2008) This special issue of Expert Review of Clinical Immunology is focused on asthma, a disorder of global importance and impact. Asthma is a syndromic disorder; the word asthma, as used clinically, amalgamates numerous different pathogenic and mechanistic pathways, genetic susceptibilities, environmental and microbial exposures, gender, age and other factors, into a clinical syndrome of variable airway obstruction, airway hyperresponsiveness and airway inflammation. The purpose of this issue is to bring much-needed attention to this common and sometimes fatal disease by summarizing current diagnostic and therapeutic strategies, exploring the boundaries of our concepts of asthma pathogenesis and treatments outlining the promise of new techniques and technologies, and providing scholarly synthesis of our understandings of immune mechanisms and their role in accentuating disease, as they interplay with existing comorbidities, environ mental sensitivities and allergen exposures.
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