FUT2 non-secretor status is associated with Type 1 diabetes susceptibility in Japanese children.

Kenji Ihara ,Goro Sasaki ,Yasuhiro Igarashi ,Shun Soneda ,Naoto Shimura ,Hidetaka Mochizuki ,Kana Takemoto ,Ichiro Yokota ,Shin Amemiya ,Sho Kanzaki ,Tatsuhiko Urakami ,Maki Fukami ,Yoshihito Kasahara ,Toru Kikuchi ,Reiko Horikawa ,Shigetaka Sugihara ,Tadayuki Ayabe ,Noriyuki Takubo ,Kohji Tsubouchi ,Nobuo Matsuura ,Kanshi Minamitani ,Shinichi Teno ,Aki Nishii ,Kenichi Kobayashi ,Rika Kizu ,Tomohiro Takahashi ,Zenro Kizaki ,Tetsuo Mori ,Tokuo Mukai ,Nobuyuki Kikuchi ,Ryuzo Takaya ,Keiichi Hanaki ,Takao Fujisawa ,Seiichiro Matsuo ,Chika Fukano ,Tsutomu Ogata ,Tomoyuki Kawamura ,Akemi Koike ,Kitaro Kosaka ,Takahiro Mochizuki ,Adolescent Diabetes

doi:10.1111/dme.13288

Abstract

To examine the contribution of the FUT2 gene and ABO blood type to the development of Type 1 diabetes in Japanese children. We analysed FUT2 variants and ABO genotypes in a total of 531 Japanese children diagnosed with Type 1 diabetes and 448 control subjects. The possible association of FUT2 variants and ABO genotypes with the onset of Type 1 diabetes was statistically examined. The se2 genotype (c.385A>T) of the FUT2 gene was found to confer susceptibility to Type 1A diabetes in a recessive effects model [odds ratio for se2/se2, 1.68 (95% CI 1.20-2.35); corrected P value = 0.0075]. The FUT2 gene contributed to the development of Type 1 diabetes in the present cohort of Japanese children.

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