Abstract
Fusion proteins between ligands for NKG2D and CD20-directed single-chain variable fragments sensitize lymphoma cells for natural killer cell-mediated lysis and enhance antibody-dependent cellular cytotoxicity
Highlights
Bournemouth, UK tion in chronic lymphocytic leukemia
The stimulatory receptor Natural killer (NK) group 2 member D (NKG2D), which is constitutively expressed by all-resting NK cells, and its Leukemia corresponding ligands have major functions in both anti- fusion protein consisting of a tumor cell-directed CD138 singlepathogen and anti-cancer immune responses
Combining therapeutic (Figures 2b – d), tumor cells were enriched from patients antibodies with bifunctional molecules such as MICA:7D8 diagnosed with chronic lymphocytic leukemia, mantle cell or ULBP2:7D8 triggering cytotoxicity independently of Fc lymphoma or marginal zone lymphoma
Summary
Bournemouth, UK tion in chronic lymphocytic leukemia. Leukemia 2009; 23: 1062–1072. 5 Lin TT, Letsolo BT, Jones RE, Rowson J, Pratt G, Hewamana S et al. Fusion proteins between ligands for NKG2D and CD20-directed single-chain variable fragments sensitize lymphoma cells for natural killer cell-mediated lysis and enhance antibody-dependent cellular cytotoxicity
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