Abstract
IntroductionDuring the last decades, Fusarium spp. has been reported as a significant cause of disease in humans, especially in immunocompromised patients, who have high risk of invasive life-threatening disease. Fusarium species usually reported as cause of human disease are F. solani, F. oxysporum and F. verticillioides.Case descriptionWe describe the second case in the literature of disseminated fusariosis caused by Fusarium napiforme, that occurred in a 60-year-old woman with multiple myeloma after subsequent cycles of chemotherapy.Discussion and EvaluationWe identified the F. napiforme not only by standard morphologic criteria by macroscopic and microscopic characteristics, but also confirmed by molecular biology methods, including sequencing. The antifungal susceptibility of the F. napiforme isolates were tested to seven antifungal drugs; the azoles were the most active drug against all the isolates tested.ConclusionsFusarium spp. are of relevance in medical mycology, and their profiles of low susceptibility to antifungal drugs highlight the importance for faster and more accurate diagnostic tests, what can contribute to an earlier and precise diagnosis and treatment.
Highlights
During the last decades, Fusarium spp. has been reported as a significant cause of disease in humans, especially in immunocompromised patients, who have high risk of invasive life-threatening disease
Fusarium species reported as cause of human disease and F. solani, F oxysporum and F. verticillioides are the most frequently species causing IF (Gupta et al 2000; Tezcan et al 2009)
The first case of disseminated fusariosis due to F. napiforme was described in 1993 (Melcher et al 1993) but, there were no subsequent reports of disseminated disease
Summary
Fusarium spp. has been reported as a significant cause of disease in humans, especially in immunocompromised patients, who have high risk of invasive life-threatening disease. Fusarium spp. has been reported as a significant cause of disease in humans, especially immunocompromised patients (Jureen et al 2008; Bourgeois et al 2010; De Pinho et al 2012; Calcaterra et al 2013). Immunocompromised hosts, mainly those with acute onco-hematological diseases or after allogeneic hematopoietic stem cell transplant, have high risk of invasive life-threatening diseases. The first case of disseminated fusariosis due to F. napiforme was described in 1993 (Melcher et al 1993) but, there were no subsequent reports of disseminated disease. To our knowledge, we describe the second case of the literature of disseminated fusariosis caused by de Souza et al SpringerPlus 2014, 3:492 http://www.springerplus.com/content/3/1/492
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