Abstract
Fusagerins A–F (1–6), six new alkaloids including a unique one with the rare a-(N-formyl)carboxamide moiety (1), a hydantoin (imidazolidin-2,4-dione) derivative (2), and four fungerin analogues (3–6), were isolated from the crude extract of the fungus Fusarium sp., together with the known compound fungerin (7). Compound 2 was isolated as a racemate and further separated into two enantiomers on a chiral HPLC column. The structures of 1–6 were determined mainly by NMR experiments, and the absolute configuration of 1 and 2 was assigned by electronic circular dichroism (ECD) calculations. Compound 7 showed antibacterial activity against Staphylococcus aureus and Streptococcus pneumoniae, and weak cytotoxicity against the T24 cells.Graphical Electronic supplementary materialThe online version of this article (doi:10.1007/s13659-015-0067-1) contains supplementary material, which is available to authorized users.
Highlights
Fungi are important sources of bioactive secondary metabolites [1], and those from special and competitive habitats are especially likely to produce structurally diverse and unique natural products due to their highly evolved secondary metabolism [2,3,4]
Our previous success in the discovery of new bioactive secondary metabolites from the of unique niches [5], a special group of fungi which were isolated from the fruiting body and larvae of Cordyceps sinensis were chemically investigated, leading to the isolation of a variety of cytotoxic natural products [6,7,8,9]
We screened the fungal species isolated from the soil samples that were collected on the Qinghai-Tibetan plateau at altitudes above 3200 m, the environment in which Cordyceps sinensis typically reside [10,11,12,13]
Summary
Fungi are important sources of bioactive secondary metabolites [1], and those from special and competitive habitats are especially likely to produce structurally diverse and unique natural products due to their highly evolved secondary metabolism [2,3,4] Based on this consideration, and our previous success in the discovery of new bioactive secondary metabolites from the of unique niches [5], a special group of fungi which were isolated from the fruiting body and larvae of Cordyceps sinensis were chemically investigated, leading to the isolation of a variety of cytotoxic natural products [6,7,8,9]. Structure elucidation, and biological activities of these compounds are reported
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