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Abstract
Four new (1–4), along with six known (5–10) dihydro-β-agarofuran sesquiterpene polyesters were isolated from the whole plants of Parnassia wightiana. The new compounds were structurally elucidated through spectroscopic analysis including UV (Ultraviolet Spectrum), IR (Infrared Spectrum), 1H-NMR (1Hydrogen-Nuclear Magnetic Resonance), 13C-NMR (13Carbon-Nuclear Magnetic Resonance), DEPT (Distortionless Enhancement by Polarization Transfer), 1H-1H COSY (1H-1H Correlation Spectroscopy), HSQC (Heteronuclear Single Quantum Coherence), HMBC (Heteronuclear Multiple Bond Correlation), NOESY (Nuclear Overhauser Enhancement Spectroscopy) and HR-MS (High Resolution Mass Specttrum) and their absolute configurations were proposed by comparison of NOESY spectra and specific optical rotations with those of known compounds and biosynthesis grounds. Compound 2 is the first sesquiterpene alkaloid isolated from this plant. New compounds 1–4 exhibited some cytotoxic activities against NB4, MKN-45 and MCF-7 cells at 20 μM and of which 4 showed the highest activity against NB4 and MKN-45 cells with inhibition rates of 85.6% and 30.5%, respectively.
Highlights
Parnassia wightiana wall (Saxifragaceae), commonly known as Ji-mei-hua-cao, Cang-er-qi, Qiao-mai-ye or Ding-chuang-cao in China, is a perennial herb and mainly distributes in QinlingMountains in China
We reported eight dihydro-β-agarofuran sesquiterpene polyesters including five new compounds isolated from this plant and their anticancer activity [1]
Some dihydro-β-agarofuran sesquiterpenes with antifeedant and antifungal activities were isolated from this plant as well [2,3]
Summary
Parnassia wightiana wall (Saxifragaceae), commonly known as Ji-mei-hua-cao, Cang-er-qi, Qiao-mai-ye or Ding-chuang-cao in China, is a perennial herb and mainly distributes in Qinling. Its dried whole plants have been used as Chinese folk medicine for the treatment of leukorrhea, cough, haematemesis, carbuncle, irregular menstruation, hypertension, malaria, kidney stones, gall stones, etc. We reported eight dihydro-β-agarofuran sesquiterpene polyesters including five new compounds isolated from this plant and their anticancer activity [1]. Some dihydro-β-agarofuran sesquiterpenes with antifeedant and antifungal activities were isolated from this plant as well [2,3]. We report four new along with six known β-dihydroagarofuran sesquiterpene polyesters have been obtained and the isolation and structural elucidation of these sesquiterpene esters
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