Abstract
Steroids have been reported to inhibit radioactive amino acid incorporation into rat adrenal protein in vitro. To study the possibility that this effect might be due to an inhibition of amino acid transport, testosterone was incubated with rat adrenal quarters and amino acid transport was measured. There was a 15% inhibition of 14C-alpha amino isobutyric acid transport but no inhibition of 14C-cycloleucine transport. When testosterone was incubated with adrenal homogenates, there was a 50% inhibition of radioactive amino acid incorporation into protein, which suggested that this steroid effect was not primarily due to an inhibition of amino acid transport. In a further study of the mechanism by which these steroids inhibit adrenal protein synthesis, it was found that the incorporation of 14C-orotic acid into RNA was inhibited by testosterone and corticosterone but not by aldosterone. (Endocrinology 83: 18, 1968)
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