Abstract
SINCE THE discovery that the thyroid secretion acts antagonistically to the follicle stimulating hormone (FSH) (1, 2), a report appeared in which it was stated that hypophysectomized female rats were more responsive to FSH than normal rats because of the hypofunction of thyroid which follows hypophysectomy (3). While studying the thyroid-hypophysis-sex relationship further, it was observed that certain extracts containing the follicle stimulating hormone did not always show the increased effectiveness in the absence of the thyroid and furthermore, other observations were at variance with those of Tyndale and Levine. In this report, we wish to present our results of studying the effect of certain menopause urine extracts, containing FSH, in thyroidectomized and hypophysectomized rats. Two different extracts of menopause urine were used. One was prepared from the urine of one individual by a tannic acid precipitation method similar to that of Levine and Tyndale.
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