Abstract
Uric acid labeled with N15 was administered to 4 normal pregnant women, 2 pre-eclamptic patients, and one patient with eclampsia during their residence on a metabolic ward under strict dietary control. It was our consistent observation that the uric acid pool was enlarged and the urinary uric acid excretion was reduced in these toxemic women. The rate of production of urate was not increased as was reported previously. The sources of error in the initial report were discussed. It is concluded that faulty renal function is the sole causative factor in urate accumulation in acute toxemia.
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