Abstract
Racemic polymers, composed of d-amino acids and decreasing amounts of l-amino acids (ranging from 42% to 3%) induced antibody formation in rabbits and delayed hypersensitivity in guinea pigs. A polypeptide composed exclusively of d-amino acids, p( d-Tyr, d-Glu, d-Lys), provoked an immune response in rabbits and in guinea pigs. In this case, the dose used for immunizing rabbits was 100 μg antigen in complete Freund's adjuvant (CFA). Antisera against either the racemic polymers or the d-amino acid polypeptide were negative in the passive cutaneous anaphylaxis (PCA) test. Antibodies against one of the racemic polymers and against the polypeptide composed exclusively of d-amino acids, were isolated by means of specific immunoadsorbents and characterized. Purified antibodies gave positive PCA reactions with homologous antigens.
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