Abstract
Crude acidic extracts of rat or beef stalk-median eminence tissue were active in releasing FSH, as judged by an increase in plasma FSH activity following intravenous injection into ovariectomized, estrogen progesterone- blocked rats. Cortical extract was inactive, as was synthetic arginine vasopressin or oxytocin. Gel nitration on Sephadex G-25 separated a peak with both FSH- and LHreleasing activity. Some fractions with LHreleasing activity contained no detectable pressor activity, but all fractions which released FSH were contaminated with pressor activity. This pressor activity was insufficient to account for the FSH release observed. It was concluded that FSH- and LH-releasing activity was caused by small molecule (s) dissimilar from vasopressin and oxytocin but of approximately similar molecular size. In all experiments larger quantities of extract were required to release FSH than to release LH. (Endocrinology 75: 901, 1964)
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