Abstract
Thirty percent D/sub 2/O in the drinking water of male Swiss mice produces sterility. Both a decrease in litter size and a decreased percentage of fertile matings were observed when treated males were mated with normal females. No increase in regressions was obtained. The development of mouse eggs in a female mated with a D/sub 2/O-treated male is generally abnormal; few multicelled eggs are obtained 2 to 2 1/2 days after copulation. It is suggested that changes in physical forces that bind macromolecules are produced by the substitution of deuterium for hydrogen. These changes may result in abnormal genetic material in developing sperm. (auth)
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