Abstract
Summary This paper records four experiments in an attempt to find a suitable antigen for the desensitization of tuberculous guinea-pigs. The antigens tested were: ether-chloroform-killed Mycobacterium tuberculosis , H 37 ; nitrous acid-killed Mycobacterium tuberculosis , H 37 ; glycerol-extract of Mycobacterium tuberculosis , H 37 ; ‘sensitized’ tuberculin (SMT); Old Tuberculin (OT); and Trichloracetic acid Precipitated Tuberculin (TPT). Bacillary antigens killed by chemical means are unsatisfactory desensitizing agents. An antigen prepared by extracting tubercle bacilli with glycerol is apparently as specific as SMT and produces satisfactory desensitization. Immunological and chemical methods which diminish the toxicity of tuberculoprotein for tuberculous guinea-pigs reduce its value as a desensitizing antigen. Old Tuberculin is not as efficient as TPT in the desensitization of tuberculous guinea-pigs.
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