Abstract
The minimum number of histocompatibility antigens by which two inbred rat strains, Lewis and DA, differ has been estimated to be 6 by F2-hybrid analysis. Of these, the antigens determined by the Ag-B locus are the most effective in dictating prompt homograft rejection. Furthermore, humoral antibodies, detectable as hemagglutinins, occur most frequently following homograft rejection when the donor-host disparity includes an Ag-B incompatibility. The data suggest that the short median survival time (7 days) of grafts exchanged between Lewis and DA rats is primarily a reflection of the antigenic disparity of the respective Ag-B antigens of the two strains.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
