Abstract
Previous experiments indicated that the development of clonic convulsions could be retarded by intraperitoneal injections of brain homogenate supernatant from male Wistar rats which had convulsed via amygdaloid electrical stimulation if two or more brain equivalents were used. Six experiments were conducted employing intracerebral injections. Although significant differences appeared in one experiment, the overall effect was one of no difference between experimental (E) and control (C) recipients. However, the mean number of trials for first clonic convulsion was greater for E and C than for E donors, and for recipients in the previous intraperitoneal experiments, suggesting possible disruption of brain function with this type of injection. Thus, two further experiments were conducted with male Wistar rats using the intraperitoneal route of injection and separating the homogenate into two fractions: molecular weight less than 500, molecular weight greater than 500. In the fraction greater than 500 molecular weight, E mean value to first clonic convulsion was greater than that for C, confirming results of the previous experiments.
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