Abstract
ALTHOUGH EXPERIMENTALLY produced overgrowth and undergrowth of the body gave convincing proof of the endocrine ‘control’ of growth by the anterior pituitary, the existence of a ‘growth hormone’ as a specific chemical entity has been challenged. The unquestioned increases in body weights and dimensions which follow the administration of certain anterior pituitary extracts have been looked upon as additive or synergistic effects from other specific pituitary hormones. One of us (1) has answered this contention elsewhere but it must be admitted that final proof that the growth hormone represents a separate entity can be obtained only by chemical separation of this hormone from the other hormones of the gland. The present paper reports a partial solution of this problem. A method of extraction and fractionation of beef anterior pituitaries has been described (2) which removes the follicle stimulating factor with the albumins and retains the growth potency in the globulin fraction.
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