Abstract
AbstractChakravarty, N. Further observations on the inhibition of histamine release by 2‐deoxyglucose. Acta physiol. scand. 1968. 72. 425–432.The effect of 2‐deoxyglucose (2‐DG) on histamine release from rat mast cells induced by compound 48/80 and antigen‐antibody reaction has been studied. In a glucose‐free oxygenated medium 2‐DG has no effect on compound 48/80‐induced histamine release and inhibits anaphylactic release only in high concentrations. Cyanide inhibition of both compound 48/80‐induced and anaphylactic histamine release is however potentiated by a low concentration (5 mM) of 2‐DG. When glucose is used to restore histamine release blocked by cyanide, 2‐DG (5 mM) markedly inhibits the release. Iodoacetate, fluoride and oxamate have a similar blocking effect on the glucose‐sustained histamine release in presence of cyanide. The findings are explained on the basis of a predominant inhibitory effect of 2‐DG on the glycolytic pathway in rat mast cells.
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