Abstract
Further observations on the growth of mouse mammary carcinomata in the strain of origin. Attempts to transfer adoptive immunity against the tumour, to isogenic hosts, with spleen cells from tumour-bearing mice.
Highlights
The tumours may be divided into three categories according to their degree of specific antigenicity
In the case of tumour 1, which retained the greatest degree of specific antigenicity, spleen cells from the spontaneous tumour bearing mouse were able to transfer adoptive immunity to the isogenic tumour recipients
Confirmation is provided for the hypothesis of Woodruff and Symes (1962a, b) that the splenic and lymph node hyperplasia of tumour bearing mice is an immunological response to the presence of tumour specific antigens
Summary
General plan of the experimentsFor each tumour to be studied the prospective A strain (isogenic) hosts were divided into three groups.Animals in the first group received, immediately before tumour transplantation, an intravenous injection of 30 million spleen cells from the animal bearing the tumour. For each tumour to be studied the prospective A strain (isogenic) hosts were divided into three groups. Animals in the first group received, immediately before tumour transplantation, an intravenous injection of 30 million spleen cells from the animal bearing the tumour. Animals in the second group received a similar injection of 30 million spleen cells from a normal A strain mouse. Donor and host animals were either of the same sex or, if of the opposite sex, female spleen cells were always injected into male recipients. The third group of animals received no spleen cells. Later on the same day all the animals in each group received a subcutaneous transplant, of equal size, from the tumour being studied
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