Abstract
Summary The mechanism of the vasodilatory effect of furosemide on the superior mesenteric artery (SMA) was investigated in dogs. The vasodilating effect of 10 mg/kg of furosemide on the SMA was unmodified by: hydration or dehydration; bilateral nephrectomy; depletion of serotonin and catecholamines by reserpine pretreatment; methysergide blockage of serotonin; α and β adrenergic blockade, and angiotensin inhibition. It is concluded that furosemide does not cause SMA vasodilatation by inhibiting the vasoconstrictor action of serotonin catecholamines or angiotensin, and its action is probably direct on vascular smooth muscle.
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