Abstract
Rats subjected to a short period of intensive treatment with DCA may develop a sustained hypertension after cessation of treatment. The percentage of rats which remain hypertensive appears to depend on the severity of treatment. Although a renal functional impairment is demonstrable in the post-DCA period, it occurs equally in those rats which do not sustain the hypertension and in those which do. The renal handling of sodium and potassium in post-DCA animals differs slightly from that of control animals, but bears no observable relation to the presence or absence of hypertension. Histologic study of both kidneys and adrenals fails to reveal any difference between normotensive and hypertensive animals. The presence of a sustained hypertension, hitherto reported on the basis of indirect blood pressure observations, has been fully confirmed by direct electromanometry.
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