Abstract
Summary Cold-virus has not proved fatal for Swiss mice when passaged in series. A few fatalities were due to associated bacteria. Cold-virus passage in ferrets has been followed in several instances by depression of body-temperature. The specificity of this has not been proven. No leucocytic reactions were observed. Both attenuated (formalin-treated) and raw viruses have been used hypodermically and intranasally in a total of 83 adult persons. The hypodermic use of cold-virus vaccine appears fairly safe; however intranasal use seems sometimes to cause colds. An irregular degree of immunity to inoculation colds may be imparted by the use of cold-virus vaccine. The evidence thus far obtained in small groups of adult subjects indicates the ineffectiveness of cold-virus vaccine in preventing natural colds.
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