Abstract
Human erythrocyte pyruvate kinase (PK) was separated by electrophoresis into two bands with different migration from L-type PK of the liver. During erythrocyte aging, alterations of these electrophoretic patterns were observed in which younger cells had denser cathodal bands than older cells. Erythrocyte PK seems to be closely related to L-type PK since erythrocyte PK could be converted to L-type PK and has the same antigenicity. Aberrant PK molecules were shown to exist by electrophoretic and immunologie studies as well as the usual kinetic studies.
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