Abstract
Results from several laboratories have indicated a close genetic and structural relationship between the murine major histocompatibility antigens, H-2K and H-2D, and the thymus-leukemia antigens. Data presented here support this concept. Electrophoretic studies show that: (1) the light chains of H-2K k, H-2D d and the thymus-leukemia antigens of ASL1 cells show indistinguishable isoelectric focusing patterns which are consistent with their identification as β2 microglobulin, and (2) there is an acid labile bond near the midpoint of the heavy chains of thymus-leukemia antigens analogous to the results with HLA (Terhorst et al., 1977). Both of these observations are consistent with the occurrence of conserved sequence homology between genes that code for major histocompatibility antigens and thymus-leukemia antigens and with their evolutionary derivation from common ancestral genes.
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