Further evidence for selective antagonism of taurine by 6-aminomethyl-3-methyl-4H-1,2,4-benzothiadiazine-1,1-dioxide

Abstract

The putative taurine antagonist 6-aminomethyl-3-methyl-4H-1,2,4-benzothiadiazine-1,1-dioxide (TAG), was examined for activity in blocking contraversive turning evoked by the injection of taurine into the substantia nigra of the rat. Microinjected intranigrally as pretreatment to taurine, TAG caused a 71% reduction in taurine elicited turning. On the other hand, TAG pretreatment did not diminish the number of turns evoked by the intranigral injection of the GABA agonist, muscimol. These results and the lack of effect of TAG in a number of central radioligand binding assays provide further indications that TAG may be a selective taurine antagonist.