Abstract
Estradiol was injected (ip) into metamorphosing tadpoles daily for 7 days. The ovaries and livers were analyzed biochemically for enzyme activity of Δ 5-3 β-hydroxysteroid dehydrogenase (Δ 5-3 β-HSD). The results indicate that the activity in both tissues was significantly decreased by estradiol injection. The findings agree well with the data of our previous experiments, where tadpole ovaries were masculinized and a Δ 5-3 β-HSD activity decrease was demonstrated histochemically after rearing tadpoles in water containing estradiol. The present evidence supplemented by our previous results shows a close relationship between decreased Δ 5-3 β-HSD activity and ovarian masculinization. Therefore, we suggest that disturbance in steroidogenesis may play a role in this abnormal sex differentiation.
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