Abstract
The distribution of brain regions involved in feeding behavior was explored by disturbing synaptic conduction and interrupting neural pathways. Food consumption of hungry rats was significantly reduced by blocking synaptic conduction (with procaine hydrochloride) in the lateral hypothalamus, anterolateral hypothalamus, and globus pallidus but not by similar disturbances in the amygdala, preoptic area, posterolateral hypothalamus, or caudate nucleus. A second experiment interrupted neural pathways with cuts in order to examine the organization of feeding circuitry in the region of the lateral hypothalamus. A severe aphagia and adipsia followed cuts in the coronal plane anterior and posterior to the lateral hypothalamus. Less severe effects occurred with cuts in the sagittal plane lateral to the hypothalamus or coronal cuts through the posterior internal capsule. There was only a transient effect with cuts through the preoptic area. These results suggest a feeding circuit which passes from the brainstem longitudinally through the lateral hypothalamus from where separate bundles pass to the anterolateral hypothalamus, globus pallidus and thalamus.
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