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Abstract
Presynaptic β-adrenoceptors were further characterized in spiral strips of guinea-pig pulmonary arteries preloaded with [ 3H]norepinephrine. l-Metoprolol (3 × 10 −6 M) inhibited isoproterenol (3 × 10 −7 M)-induced increases in 3H efflux by transmural field stimulation, whereas the d-isomer produced to inhibition. However, IPS 339, H 35 25 , butoxamine and metoprolol (3 × 10 −6 M) antagonized salbutamol (3 × 10 −7 M)-induced increases in the parameter, whereas acebutolol, bevantolol and practolol (3 × 10 −6 M) produced no antagonism. Presynaptic β-adrenoceptors in guinea-pig pulmonary arteries appear to have characteristics similar to those postsynaptic classical β-adrenoceptors.
Published Version
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