Furosemide Determination in Pharmaceutical Samples Using Differential Pulse Polarographic method

Abstract

The research includes the development of a simple, sensitive and accurate differential pulse polarography method for the quantitative determination of furosemide drugs in pharmaceutical preparations and in their pure and commercial forms, the electrochemical behavior using the dropping mercury electrode DME, as well as finding the values of the half-wave potential (E1/2) as a qualitative value, the number of electrons that were transferred and participating in the reduction process. The furosemide drug showed a clear reduction peak at a voltage of (-0.24) volts under optimal conditions. The correlation coefficient for furosemide at a concentration range of (2–24) µg.ml-1 was 0.9969, the LOD and LOQ of the drug were 2.139 and 7.129, respectively, and the average relative standard deviation (RSD) of the drug was 1.41%, with recovery of the f drug 97.58% and (n =5).