Fungous infections of the skin treated with pyrrobutamine compounds.

Abstract

The in vitro fungistatic activity of certain antihistamine drugs has been previously recorded. Apparently there is considerable variation among different members of this group of agents in this regard. Some are altogether incapable of inhibiting fungi, whereas others possess this characteristic in varying degree. Carson and Campbell 1 demonstrated the in vitro fungistatic activity against several species of pathogenic fungi (Trichophyton mentagrophytes, Trichophyton rubrum, Trichophyton ferrugineum, Microsporum gypseum, Microsporum canis and Epidermophyton floccosum) of diphenylpyraline, antazoline (Antistine), and tripelennamine (Pyribenzamine). Concentrations as low as 0.1 mg/ml. were capable of restricting the growth of some of the organisms, but higher levels of more than 1 mg/ml. were required for complete suppression of certain fungi. Carson and Campbell found that the fungistatic effect of the drugs tested could be reduced or abolished in media adjusted to pH 5 and that for tripelennamine there was an