Abstract
We propose a novel cancer treatment which involves blocking newborn blood vessels around the diseased part. This treatment has minimal side effects and is less invasive. In the therapy, ferromagnetic particles administered into the body are accumulated in the newborn blood vessels. Next, the particles are aggregated to block the blood vessels to prevent cancer growth and metastasis. In this study, we modified the surface of magnetite particles with biocompatible polyacrylic acid to design particles that form irreversible aggregation on the application of a magnetic field. We succeeded in blocking only the flow path under a uniform magnetic field using the prepared particles, as is verified by the results of a model experiment. We assume that the blockage occurred due to the formation of chain aggregation under the magnetic field and the increase in pressure loss.
Highlights
Therapeutic embolization that treats cancer by blocking blood vessels around the cancer tissues with microgel is expected to be a less invasive treatment method with few side effects
Blockages to the newborn blood vessels are formed around the cancer tissue by magnetic aggregation, which can prevent cancer growth and metastasis
The surface of the magnetite particles was modified with polyacrylic acid as a negatively charged polymer is needed for the modification
Summary
Therapeutic embolization that treats cancer by blocking blood vessels around the cancer tissues with microgel is expected to be a less invasive treatment method with few side effects This treatment requires the skill to guide a catheter to the vicinity of the cancer tissue via angiography.. This treatment requires the skill to guide a catheter to the vicinity of the cancer tissue via angiography.1 This mode of treatment is limited to specific organs such as the liver, as it is tough to implement and is high risk.. This mode of treatment is limited to specific organs such as the liver, as it is tough to implement and is high risk.2 To solve this problem, we propose a novel cancer therapy by blocking newborn blood vessels. Blockages to the newborn blood vessels are formed around the cancer tissue by magnetic aggregation, which can prevent cancer growth and metastasis
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