Abstract
The individualized process of human aging occurs in the intersection of biological, cognitive, and psychological domains. Advances in the field of biochirality reveal new crucial determinants of aging at the molecular, cellular, and organism levels. All biologic macromolecules, including DNA, proteins, and lipids, exhibit a prevalence of chirality. Chirality and stereoselectivity are recognized as the fundamental properties of all life-supporting biomolecular systems. However, all homochiral molecules are vulnerable to multiple types of spontaneous aberrant modifications, including racemization. Indeed, several biomolecular structures, including amyloids, are known as the by-products of the major evolutionary pathway. Accumulation and aggregation of misfolded proteins are commonly recognized biomarkers of biological aging, neurodegenerative, immune, and psychiatric disorders. Aging, accompanied by the decline in health, independence, perceptual, cognitive, and decision-making abilities, is closely associated with the negative impacts of most typical psychological stress. Both aging and psychological stress aversively affect the immune, hormonal, and neuro-transmitting systems. In our view, at the protein level, the primary determinants contributing to the crosstalk of genetic, epigenetic, and psychological pathways of aging are the spontaneous post-translational modifications.
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