Functions and related molecular mechanisms of BPTF in tumorigenesis and development

Abstract

<p indent=0mm>Chromatin remodeling is involved in gene transcriptional regulation as it affects the chromatin opening status. As the largest subunit of chromatin remodeling complex, bromodomain PHD-finger transcription factor (BPTF) containing bromine domain and zinc finger structure can regulate gene expression through various ways, such as participating in chromatin remodeling and affecting DNA accessibility; acting as independent transcription factors; synergistically acting with other transcriptional factors, histone or long-chain noncoding RNAs, and is involved in tumorigenesis and development to promote cancer progression by influencing cellular proliferation, migration and invasion, stemness maintenance, immune response, and other biological processes. This paper reviews the structure of BPTF, the function and related molecular mechanism of BPTF in tumor development and its expression regulation mechanism, as well as the development and application status of small-molecule inhibitors based on their structure and function.