Functions and regulations of the Store Operated CRAC channels

Abstract

Store-operated Ca2+ channels, or SOCs, contain the main Ca2+ activated-receptor signaling pathways in non-excitable cells and play key roles in several biological and signaling pathways such gene, Ca2+ secretion and homeostasis and the differentiation of cells. Ca2+ signaling is associated with CRAC channels and it is essential and critical for activation of T and B cells. Cell receptors stimulated by antigens thus lead to the accumulation of huge and distinct CRAC signaling complexes. Several studies have revealed in mast and T cells Ca2+ influxes across plasma membrane and SOC activation after depletion of intracellular Ca2+ pool. Targeting CRAC channels pharmacologically have the possible therapy to be used therapeutically for angiogenesis modulation in many tumors, metabolic disorders such as fatty liver diseases, obesity or for autoinflammatory diseases and allergic conditions.