Abstract
Functions and computational principles of serotonergic and related systems at multiple scales
Highlights
As one of the phylogenetically and ontogenetically oldest neurotransmitters, the monoamine serotonin (5-HT) is derived from tryptophan in neurons within the raphe nuclei, and innervates various parts of the nervous system (Jacobs and Azmitia, 1992)
At the receptor and cellular levels, Maejima et al (2013) discussed various G protein-coupled receptors (GPCRs) and ion channels in the serotonin regulation and introduced optogenetic techniques that modulate intracellular signaling to more finely control the serotonergic systems for studies of their functions
The activation of the serotonin receptors was determined by its release and uptake dynamics
Summary
As one of the phylogenetically and ontogenetically oldest neurotransmitters, the monoamine serotonin (5-HT) is derived from tryptophan in neurons within the raphe nuclei, and innervates various parts of the nervous system (Jacobs and Azmitia, 1992). Unlike previous collections, neurobiologically based computational studies are included in this collection as we consider them to be important toward elucidating some of the underlying principles, especially at the systems level. These works include original results, reviews, and hypothesis over multiple levels: from receptors and channels, to neuronal circuits and to behavior and neuropsychiatric disorders.
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