Abstract
Introduction: Oncocytic neoplasms of the adrenal cortex are extremely rare and are usually nonfunctioning. Only a little more than fifty cases have been described in the literature. Case Presentation: We report the case of an adrenocortical oncocytic neoplasm with malignant potential in a 21-year-old female with co-secrete testosterone and cortisol. The patient had been operated of adrenal mass. Fallowing operation, the Cushing’s syndrome and high testosterone levels resolved. Conclusion: In our knowledge this is the first case in the l?terature which co-secret cortizol and testosterone in malign oncystoma.
Highlights
Oncocytic neoplasms of the adrenal cortex are extremely rare and are usually nonfunctioning
Case Presentation: We report the case of an adrenocortical oncocytic neoplasm with malignant potential in a 21-year-old female with co-secrete testosterone and cortisol
We report here a rare case of functioning adrenocortical oncocytic carsinoma which cosecrete testosterone and cortisol
Summary
The term “oncocyte”, first used by Hamperl in 1950, describes large, highly eosinophilic, granular cells associated with a hurthle cell tumor of the thyroid gland [1]. An oncocytoma is a tumor which is composed predominantly of polygonal oncocytes with abundant granular and intensely eosinophilic cytoplasm [2]. It occurs in several organs, most commonly in the kidney, salivary glands, and thyroid and less commonly in lung, parathyroid gland, ovary or pituitary gland [2]. Adrenocortical oncocytic neoplasms represent unusual lesions and three histological categories are included: oncocytoma, oncocytic neoplasm of uncertain malignant potential and oncocytic carcinoma [5]. Most of these adrenal oncosytic neoplasms are detected incidentally and usually benign and nonfunctioning [6]. We report here a rare case of functioning adrenocortical oncocytic carsinoma which cosecrete testosterone and cortisol
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