Abstract
DNA is a very useful molecule for the programmed self-assembly of 2D and 3D nanoscale objects.[1] The design of these structures exploits Watson–Crick hybridization and strand exchange to stitch linear duplexes into finite assemblies.[2–4] The dimensions of these complexes can be increased by over five orders of magnitude through self-assembly of cohesive single-stranded segments (sticky ends).[5,6] Methods that exploit the sequence addressability of DNA nanostructures will enable the programmable positioning of components in 2D and 3D space, offering applications such as the organization of nanoelectronics,[7] the direction of biological cascades,[8] and the structure determination of periodically positioned molecules by X-ray diffraction.[9] To this end we present a macroscopic 3D crystal based on the 3-fold rotationally symmetric tensegrity triangle[3,6] that can be functionalized by a triplex-forming oligonucleotide on each of its helical edges.
Highlights
DNA is a very useful molecule for the programmed self-assembly of 2D and 3D nanoscale objects.[1]
The tensegrity triangle is a robust motif consisting of three helices directed along linearly independent vectors.[3]
By tailing the helices with sticky ends, each triangle can associate with six others, along three different directions, yielding rhombohedral DNA crystals.[6]
Summary
DNA is a very useful molecule for the programmed self-assembly of 2D and 3D nanoscale objects.[1]. Mao Department of Chemistry, Purdue University West Lafayette, IN 47907 (USA) C. Seeman Department of Chemistry, New York University New York, NY 10003 (USA) E-mail: ned.seeman@nyu.edu
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