Abstract
Organic–inorganic nanocomposites for photothermal therapy of cancers emerged as a promising strategy against malignant tumors. However, it is still a big challenge to develop a nanocomposite system that can maximize the synergistic photo-thermal therapy effect as well as preserve high stability for simultaneous delivery of the chemotherapeutic drugs and photo-thermal agents. Here, we have exploited an organic liposome containing inorganic core for co-loading the aggregates of bovine serum albumin (BSA), indocyanine green (ICG), and doxorubicin (DOX), abbreviated as BID-liposomal nanocomposites. The three kinds of substances were aggregated in the core of liposomal nanocomposites through hydrophobic and electrostatic interactions. In vitro characterization shows that BID-liposomal nanocomposites were spherical nanoparticles with size of 30–50 nm and good storage stability. Moreover, BID-Liposomal nanocomposites illustrate the strongest cytotoxicity among all the formulations against murine 4T1 tumor cells. In breast cancer-bearing mouse models, BID liposomes lead to significant improvements in tumor inhibition effects with no obvious toxicity. Therefore, the BID-liposomal nanoparticle is believed to be a promising strategy for chemo-photo-thermal therapy against cancers.
Highlights
As one of the standard-of-care cancer treatments, chemotherapy has been in a dilemma due to lack of tissue targeting and dose-limiting toxicities (Fan et al, 2017)
® albumin (BSA), indocyanine green (ICG), and IGEPAL CO-520 were obtained from Sigma-Aldrich, Inc.; phospholipids (DOTAP, DOPA, and DSPE-PEG2000) were ordered from Avanti Polar Lipid, Inc
ICG and DOX could be formed into aggregates through electrostatic attraction, these aggregates are unstable, especially in a complex environment in vivo (Figure 1)
Summary
As one of the standard-of-care cancer treatments, chemotherapy has been in a dilemma due to lack of tissue targeting and dose-limiting toxicities (Fan et al, 2017). Besides the application in disease imaging, ICG is widely applied in the area of photothermal therapy due to its strong absorption ability and a good photothermal conversion ability. It is limited by the defect of easy diffusion in vivo and repeated-irradiation causing photothermal conversion instability (Shan et al, 2018; Liu et al, 2019b). We proposed to develop efficient chemo-photo-thermal composite systems of liposomal nanocomposites co-loading three components of ICG, DOX, and BSA. The cytoxicity and in vivo antitumor activity were investigated in various breast cancer cells and tumorbearing mouse models
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