Abstract
Gastrointestinal malignancies have been a tremendous problem in the medical field and cover a wide variety of parts of the system, (i.e. esophagus, duodenum, intestines, and rectum). Usually, these malignancies are treated with palliation with the use of non-vascular nitinol stents. However, stenting is not a perfect solution for these problems. While it can enhance the quality of life of the patient, in time the device will encounter problems such as re-occlusion due to the rapid growth of the tumor. In this study, we propose a functionalization technique using electropolymerization of polydopamine directly onto the nitinol stent struts for the combined application of hyperthermia and chemotherapy. The coating was characterized using FESEM, XPS, and FT-IR. Drug release studies show that facile release of the anticancer drug BTZ from the surface of the polydopamine-coated stent could be achieved by the dissociation between catechol groups of polydopamine and the boronic acid functionality of BTZ in a pH-dependent manner. The anti-cancer property was also evaluated, and cytotoxicity on ESO26 and SNU-5 cancer cell lines were observed. Our results suggest that the introduced approach can be considered as a potential method for therapeutic stent application.
Highlights
Gastrointestinal malignancies have been a tremendous problem in the medical field and cover a wide variety of parts of the system
The deposition of the coating can be determined by the decrease in conductivity of the working electrode as seen in Fig. 1D, where the conductivity of the working electrode is inversely proportional to the thickness of the polydopamine coating[9]
The reduction of dopamine in the solution can be verified by the CV graph in Fig. 1E, where anodic peaks can be noted, indicative of redox couples of dopamine/dopamine quinone, the peak area decreased every after scanning as a result of the deposition of the polydopamine thin film on the nitinol stent strut
Summary
Ludwig Erik Aguilar[1], Batgerel Tumurbaatar[1,3], Amin Ghavaminejad[1], Chan Hee Park1,2 & Cheol Sang Kim[1,2,4]. By polymerizing dopamine onto the stent, we can utilize its catechol moiety to bind to the boronic acid functional group of the anti-cancer drug bortezomib (BTZ)[9,13]. We partnered a controlled drug release system through the pH sensitive binding between bortezomib (BTZ) and catechol groups of polydopamine and an effective hyperthermia therapy by subjecting the nitinol stent under the external alternating magnetic field to increase its temperature to hyperthermic conditions. Drug release studies show that facile release of the anticancer drug BTZ from the surface of the polydopamine-coated stent could be achieved due to the dissociation between catechol groups of polydopamine and the boronic acid functionality of BTZ. The anti-cancer property of the stent was evaluated and cytotoxicity on ESO26 and SNU-5 cancer cells were observed
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
