Abstract
Multi walled carbon nanotubes (MWNTs) have been identified as an efficient drug carrier. Here a controlled drug delivery system based on modified MWNTs with polyethylene glycol (PEG) was developed (MWNTs-PEG). Then doxorubicin (DOX) as an anticancer drug loaded to nanocarrier. All the parameters affecting the DOX adsorption such as: dose of adsorbent, pH, initial DOX concentration and contact time were studied for the first time by factorial design methodology to evaluate and optimize the adsorption conditions. The adsorption isotherm and other properties including kinetics and thermodynamics were studied. The adsorption isotherm was well described by the Freundlich model and adsorption kinetics followed a pseudo-second order model. The thermodynamic studies showed that the adsorption of DOX on nanocarrier is spontaneous and exothermic in nature. The cumulative release of DOX from MWNTs-PEG was pH dependent and the release rate was much higher at pH 5.5 than that at pH 7.4.
Highlights
Since carbon nanotubes (CNTs) discovery in the early 1990s,1,2 they have become an area of a wide ranging research activity due to their exceptional chemical and physical properties.[3,4,5,6,7,8,9,10,11,12] The development of new and efficient drug delivery system has fundamental importance to improve the pharmacological profiles of many classes of therapeutic molecules
Whereas the surfaces of carbon nanotubes in Multi walled carbon nanotubes (MWNTs)-polyethylene glycol (PEG) were rough and exist some clusters attached to them (Figure 2b)
The phenomenon indicates that PEG macromolecular has been grafted on the surface of MWNTs by the formation of ester linkages between the reactive hydroxyl groups of PEG and the acyl groups of MWNTs
Summary
Since carbon nanotubes (CNTs) discovery in the early 1990s,1,2 they have become an area of a wide ranging research activity due to their exceptional chemical and physical properties.[3,4,5,6,7,8,9,10,11,12] The development of new and efficient drug delivery system has fundamental importance to improve the pharmacological profiles of many classes of therapeutic molecules. Many different types of drug delivery systems are currently available. Within the family of nanomaterials, CNTs have emerged as a new alternative and efficient tool for transporting and translocating therapeutic molecules. CNTs possess many intriguing features that make them attractive drug delivery carriers.
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