Abstract
BackgroundMolybdenum disulfide (MoS2) has been widely explored for biomedical applications due to its brilliant photothermal conversion ability. In this paper, we report a novel multifunctional MoS2-based drug delivery system (MoS2-SS-HA). By decorating MoS2 nanosheets with hyaluronic acid (HA), these functionalized MoS2 nanosheets have been developed as a tumor-targeting chemotherapeutic nanocarrier for near-infrared (NIR) photothermal-triggered drug delivery, facilitating the combination of chemotherapy and photothermal therapy into one system for cancer therapy.ResultsThe nanocomposites (MoS2-SS-HA) generated a uniform diameter (ca. 125 nm), exhibited great biocompatibility as well as high stability in physiological solutions, and could be loaded with the insoluble anti-cancer drug erlotinib (Er). The release of Er was greatly accelerated under near infrared laser (NIR) irradiation, showing that the composites can be used as responsive systems, with Er release controllable through NIR irradiation. MTT assays and confocal imaging results showed that the MoS2-based nanoplatform could selectively target and kill CD44-positive lung cancer cells, especially drug resistant cells (A549 and H1975). In vivo tumor ablation studies prove a better synergistic therapeutic effect of the joint treatment, compared with either chemotherapy or photothermal therapy alone.ConclusionThe functionalized MoS2 nanoplatform developed in this work could be a potent system for targeted drug delivery and synergistic chemo-photothermal cancer therapy.
Highlights
Molybdenum disulfide (MoS2) has been widely explored for biomedical applications due to its brilliant photothermal conversion ability
The morphology of prepared M oS2-SS-hyaluronic acid (HA) was characterized by atomic force microscope (AFM) images, which shows the material to consist of exfoliated sheets (Fig. 2b), the results are consist with the literature of molybdenum disulfide (MoS2) [51]
The photothermal effect is found to be concentration-dependent under irradiation at 0.5 W/cm2 (Fig. 3c). These results indicate the suitability of MoS2-SS-HA for photothermal therapy and potent suspension remains largely constant
Summary
Molybdenum disulfide (MoS2) has been widely explored for biomedical applications due to its brilliant photothermal conversion ability. A multitude of nanomaterials have been designed as they exhibit promising potential to overcome the limitations of chemotherapy drugs for cancer therapy applications, such as liposomes [8], carbon nanomaterials [9], silica nanoparticles [10], metal-based nanoparticles [11], polymeric nanoparticles [12,13,14] and quantum dots [15, 16] have been used in biomedical applications Compared to these nanomaterials, two-dimensional (2D) nanomaterials possess exceptional chemical, optical, and electronic properties and are being considered as novel therapeutic agents for biomedicine, especially for cancer treatment. The novel approach for the surface modification of single-layer MoS2 nanosheet is urgently needed
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